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Abstracts |

Renal Osteodystrophy During Chronic Dialysis.

Saul M. Genuth, M.D.; Leonard Berman, M.D., F.A.C.P.; and Victor Vertes, M.D., F.A.C.P.
Ann Intern Med. 1969;70(5):1094. doi:10.7326/0003-4819-70-5-1094_1
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Renal osteodystrophy includes a spectrum of metabolic bone disorders ranging from osteomalacia due to calcium lack to osteitis fibrosa cystica due to secondary or tertiary hyperparathyroidism. To better define a physiological guide to therapy, patterns of response to a standardized intravenous calcium infusion were studied in patients undergoing chronic dialysis. Patients with severe X-ray changes of osteitis fibrosa demonstrated significantly lesser increments in plasma calcium with a significant coincident fall in plasma phosphorus when compared with similarly dialyzed controls, suggesting rapid assimilation of calcium by unmineralized bone. Plasma parathormone, measured by radioimmunoassay, was four times higher in bone-disease patients than


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