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The Effects of Cigarette Smoking on the Ultrastructure of the Human Bronchus.

Geoffrey L. Brinkman, M.D., F.A.C.P.
Ann Intern Med. 1969;70(5):1097. doi:10.7326/0003-4819-70-5-1097_1
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Excessve cigarette smoking causes squamous metaplasia of the bronchial mucosa, but before this degree of damage becomes apparent it may be possible to detect changes in cigarette smokers in the ultrastructural appearance of the bronchial epithelium. Bronchial biopsies were obtained during lung resection and immediately fixed in 3% gluteraldehyde and postfixed with osmium. After embedding in Vestophal-W and staining with uranyl magnesium acetate, the specimens were examined by light microscopy and electron microscopy.

In cigarette smokers, some or all of the following changes were noted. Bronchial epithelial cells may change from a cylindrical to cuboidal shape while proliferating in number.



smoking ; bronchi

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