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Effect of Weight Loss and Triiodothyronine on Plasma Growth Hormone and Insulin in Obesity.

G. A. Bray, M.D.; J. Londono, M.D.; and T. F. Gallagher Jr., M.D.
Ann Intern Med. 1969;70(5):1100. doi:10.7326/0003-4819-70-5-1100_3
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Twenty-three obese patients (19 females) had a reduced response to stimuli that usually increase growth hormone. They were studied before and after diethylstilbestrol, weight loss, or triidothyronine, or a combination. Diethylstilbestrol, 5 mg twice a day for 2 days, in four women did not alter their initial, flat growth, hormone response to intravenous arginine. After weight loss ranging from 6 to 60 kg, fasting plasma insulin decreased by an average of 6 µunits/ml, and the postinsulin rise in growth hormone was increased. This increase was directly proportional to the absolute weight loss. Weight loss also augmented the rise in growth


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