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Abstracts |

Immunoassay of Glycoprotein in Gastric Cancer Secretion.

Emmanuel Deutsch, M.D., F.A.C.P.; and Haruki Mori, M.D.
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Boston, Massachusetts


Ann Intern Med. 1969;70(5):1105-1106. doi:10.7326/0003-4819-70-5-1105_3
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In the differentiation of benign from malignant ulcer of the stomach a gastric secretion protein, specific for human gastric cancer, would have great practical diagnostic value. When antisera are prepared against gastric cancer secretion, it is possible to make an antiserum by suitable absorptions which is highly specific for this lesion. An alpha-2 glycoprotein that migrates in the globulin range has been found on immunoelectrophoretic analysis in gastric secretion of patients with gastric carcinoma.

Ninety-nine coded and randomized gastric juice specimens from patients with major lesions of the stomach were assayed against this absorbed antiserum. Of 18 known gastric cancer

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