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Consumption Coagulopathy and Acute Renal Failure Due to Gram-Negative Septicemia After Abortion: Complete Recovery with Heparin Therapy

A. R. CLARKSON, M.B., M.R.A.C.P.; R. E. SAGE, M.B., M.R.A.C.P.; and J. R. LAWRENCE, M.B., F.R.A.C.P.
Ann Intern Med. 1969;70(6):1191-1199. doi:10.7326/0003-4819-70-6-1191
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A case of acute renal failure with consumption coagulopathy in a young woman with gram-negative septicemia complicating induced abortion is described. The features of her illness resembled those of the generalized Shwartzman reaction. Prompt recognition of the syndrome allowed early heparin therapy that, although initially inadequate, may have averted the complication of renal cortical necrosis and led to full clinical recovery. Problems in treatment arose with the use of epsilon-aminocaproic acid and the decision to cease anticoagulant therapy. The use of the FI-test as a measure of split products of fibrinogen and as a monitor of the coagulation disorder is emphasized.





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