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Immunosuppressive Drugs in Rheumatoid Arthritis

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The University of Rochester School of Medicine and Dentistry
Rochester, N. Y.

Ann Intern Med. 1969;71(1):202-204. doi:10.7326/0003-4819-71-1-202
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"Immunosuppressive" therapy is being used more and more in the treatment of rheumatoid arthritis. Its potential role has been recognized by a committee of the American Rheumatism Association which is conducting a well-controlled multiclinic study of cyclophosphamide in this disease. The immunosuppressive drugs that have been used in the treatment of rheumatoid arthritis are nitrogen mustard (1-3), azathioprine (4-9), 6-mercaptopurine (9-11), chlorambucil (12-14), cyclophosphamide (15), and methotrexate (16).

Recently, Mason and his colleagues (4) of the London Hospital published a preliminary communication on a double-blind study of azathioprine in "severe cases" of rheumatoid arthritis with long-term steroid therapy. The study


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