0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Interferon in Human Infections with St. Louis Encephalitis Virus

JAMES P. LUBY, M.D.; WILLIAM E. STEWART II, PH.D.; S. EDWARD SULKIN, PH.D.; and JAY P. SANFORD, M.D., F.A.C.P.
Ann Intern Med. 1969;71(4):703-709. doi:10.7326/0003-4819-71-4-703
Text Size: A A A
SUMMARY:

The epidemic of St. Louis encephalitis in Dallas, Tex., 1966, afforded an opportunity to assess the role of interferon in human infections with this virus. Ninety-seven sera from 74 patients and 13 urine specimens from 13 patients, all with laboratory-documented St. Louis encephalitis and collected, for the most part, during the first week of illness, had no detectable interferon. Suspensions of different sections of brain, liver, kidney, and spleen from eight patients dying with St. Louis encephalitis were also assayed. Interferon was detected in suspensions of brain from three patients from whom St. Louis encephalitis virus was isolated and who died early in the course of illness. Two patients had St. Louis encephalitis virus isolated from brain but had no detectable interferon. These two patients had severe underlying illnesses: chronic lymphocytic leukemia and arteriolar nephrosclerosis with uremia. The remaining three patients died later in the course of illness, and neither virus nor interferon could be demonstrated in postmortem specimens.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)