0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

The Response of Patients with "Idiopathic" Obstructive Pulmonary Disease and "Allergic" Obstructive Bronchitis to Prednisone

RUSSELL C. KLEIN, M.D.; JOHN E. SALVAGGIO, M.D.; and V. G. KUNDUR, M.D.
[+] Article and Author Information

New Orleans, Louisiana


Ann Intern Med. 1969;71(4):711-718. doi:10.7326/0003-4819-71-4-711
Text Size: A A A
SUMMARY:

In a controlled study 18 patients with "idiopathic" obstructive lung disease and a long history of cigarette smoking and 14 with "allergic" obstructive bronchitis (bronchial asthma) were placed on ephedrine sulfate and isoproterenol aerosol. After 7 days prednisone was added. As a group, subjects with active "allergic" obstructive bronchitis showed significant improvement in ventilatory function after prednisone (P = 0.01). The overall response was also significantly greater in this group than in those with "idiopathic" obstructive lung disease after bronchodilators ( P = 0.05 ) and after prednisone ( P = 0.005 ). Although no overall improvement was noted in the "idiopathic" obstructive lung disease group after prednisone, 6 of the 18 subjects noted improvement in spirometrie values. Our data suggest that steroid responsiveness was associated with an atopic component in these individuals. There were no early complications from steroid therapy in any of the 32 subjects although follow-up studies showed exudative pericarditis in one individual who was maintained on low-dose prednisone and died 4 months after the study was completed. We believe that a brief trial of corticoids is justified in patients with clinically diagnosed "idiopathic" chronic obstructive lung disease if obstruction does not remit with conventional bronchodilators alone provided that frequent objective, as well as subjective, assessment is made.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)