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Megaloblastic Anemia of Pregnancy Simulating Acute Leukemia

PAUL H. LEVINE, M.D.; and ROGER D. HAMSTRA, M.D.
Ann Intern Med. 1969;71(6):1141-1147. doi:10.7326/0003-4819-71-6-1141
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SUMMARY:

Two patients had megaloblastic anemia of pregnancy, presenting with histories and bone marrow smears compatible with acute granulocytic leukemia. A review of the reported cases of acute leukemia in pregnancy indicates the difficulty in making a definitive diagnosis on the basis of clinical history and smears of the blood and bone marrow.

The role of concurrent iron deficiency in obscuring the diagnosis of megaloblastic anemia is suggested. A brief trial of folic acid and vitamin B12 is indicated in all patients with equivocal marrow findings or the possibility of vitamin deficiency.

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[Vitamin B(12) deficiency anaemia in a 7.5 months old girl]. Med Wieku Rozwoj 2004 Apr-Jun;8(2 Pt 1):283-8.
[Clinical analysis of bicytopenia and pancytopenia during pregnancy]. Zhonghua Fu Chan Ke Za Zhi 2009;44(7):488-91.
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