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Megaloblastic Anemia of Pregnancy Simulating Acute Leukemia

Ann Intern Med. 1969;71(6):1141-1147. doi:10.7326/0003-4819-71-6-1141
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Two patients had megaloblastic anemia of pregnancy, presenting with histories and bone marrow smears compatible with acute granulocytic leukemia. A review of the reported cases of acute leukemia in pregnancy indicates the difficulty in making a definitive diagnosis on the basis of clinical history and smears of the blood and bone marrow.

The role of concurrent iron deficiency in obscuring the diagnosis of megaloblastic anemia is suggested. A brief trial of folic acid and vitamin B12 is indicated in all patients with equivocal marrow findings or the possibility of vitamin deficiency.





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