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A Comparison of Serum Immunoglobulin Concentrations in Sarcoidosis and Tuberculosis

C. E. BUCKLEY III, M.D.; and F. C. DORSEY, M.A.
[+] Article and Author Information

Supported by grant AI07499-03, U.S. Public Health Service, Washington D.C.; and grant AMA-ERF, the American Medical Association, Chicago, Ill.

Dr. Buckley was supported in part by a Research Career Development Award 5-K3-AI-14,797, U.S. Public Health Service, Washington, D.C.

▸Requests for reprints should be addressed to Dr. C. E. Buckley, III, Box 3804, Duke University Medical Center, Durham, N.C. 27706


Durham, North Carolina


Ann Intern Med. 1970;72(1):37-42. doi:10.7326/0003-4819-72-1-37
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Changes in the three major immunoglobulins in patients with sarcoidosis and tuberculosis were studied with respect to age, race, and sex. IgG and IgM were increased in patients with sarcoidosis, IgG in patients with tuberculosis. Differences between serum immunoglobulin concentrations in patients with sarcoidosis and tuberculosis were not significant. The restriction of significant hyperglobulinemia to specific race and sex combinations was of special interest. In patients with sarcoidosis the increase in IgG was significant in white patients, and the increase in IgM was significant only in black patients. A similar race-associated pattern could be demonstrated in patients with tuberculosis. Evaluation of hyperglobulinemia with respect to sex showed that the increase in IgM in sarcoidosis was only significant in black women. White men with tuberculosis showed increased IgG and IgA. Changes observed in specific race and sex combinations may provide a basis for interrelating these differences with variations in the natural history of each disease.

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