The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

"Rheumatoid" Nodules in Systemic Lupus Erythematosus

[+] Article, Author, and Disclosure Information

Supported in part by graduate training grant in arthritis 5 T01-AM-95933-14 and Clinical Research Center grant 5 M01 FR 35, U. S. Public Health Service, Washington, D. C., and by the Arthritis Clinical Research Center grant of the Arthritis Foundation.

▸Requests for reprints should be addressed to Mary Betty Stevens, M.D., 916 Blalock Bldg., The Johns Hopkins Hospital, Baltimore, Md. 21205

Baltimore, Maryland

Ann Intern Med. 1970;72(1):49-58. doi:10.7326/0003-4819-72-1-49
Text Size: A A A

Six patients with systemic lupus erythematosus (SLE) and periarticular subcutaneous nodules are described. The nodules were biopsied in three patients. Each specimen was histologically typical of the well-developed "rheumatoid" nodule. The features of SLE in these patients included fever, constitutional symptoms, polyarthritis, skin rash, serositis, glomerulonephritis, anemia, and leukopenia. All had lupus erythematosus cells, antinuclear antibodies, and reduced serum complement. The latex test was negative in three patients and only transiently positive in the other three. When present, the subcutaneous nodule was invariably associated with clinically active SLE. In the patient with polyarthritis the presence of periarticular subcutaneous nodules may be a hallmark of SLE as well as rheumatoid arthritis.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.