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Hyponatremia Due to Chlorpropamide: A Syndrome Resembling Inappropriate Secretion of Antidiuretic Hormone

DANIEL FINE, M.D.; and HECTOR SHEDROVILZKY, M.D.
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▸Requests for reprints should be addressed to Daniel Fine, M.D., New Kensington Clinic, New Kensington, Pa. 15068.


New Kensington, Pennsylvania


Ann Intern Med. 1970;72(1):83-87. doi:10.7326/0003-4819-72-1-83
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A syndrome resembling inappropriate secretion of antidiuretic hormone (ADH) occurred in a 78-year-old diabetic woman receiving chlorpropamide; it abated when the drug therapy was stopped and water intake was reduced. Water retention, hyponatremia, natriuresis, and symptoms of water intoxication reappeared when chlorpropamide therapy was reinstituted and were reversed by withdrawal of the drug or restriction of water intake. This disorder develops from the ADH-like action of chlorpropamide in a susceptible patient maintaining a generous intake of water. This syndrome may not be uncommon and may aggravate the abnormal handling of water by the kidneys which, because it is also seen in other disorders, may lead to an erroneous diagnosis.

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