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Long-Term Continuous Oxygen Therapy in Chronic Airway Obstruction: Mortality in Relationship to Cor Pulmonale, Hypoxia, and Hypercapnia

THOMAS A. NEFF, M.D.; and THOMAS L. PETTY, M.D.
[+] Article and Author Information

Supported in part by contract 108-66-227, Chronic Respiratory Disease Control Program, U. S. Public Health Service, Washington, D.C. Findings and conclusions do not necessarily represent the views of the U. S. Public Health Service.

▸Requests for reprints should be addressed to Thomas L. Petty, M.D., Department of Medicine, University of Colorado Medical Center, Denver, Colo. 80220


Denver, Colorado


Ann Intern Med. 1970;72(5):621-626. doi:10.7326/0003-4819-72-5-621
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Thirty-three patients received continuous oxygen therapy from 7 to 41 months. The increased mortality associated with cor pulmonale and severe hypoxia was reduced 30% and 40%, respectively, by this form of therapy when contrasted to other results reported in the literature. Continuous oxygen therapy does not prevent the late development of cor pulmonale, but it does make management significantly more effective when used with an overall care program. Continuous oxygen therapy has little beneficial effect on the mortality of patients with chronic airway obstruction when severe hypoxia or cor pulmonale is not present.

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