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Melphalan and Myeloma: Experience with a Low-Dose Continuous Regimen

JAMES R. MCARTHUR, M.D.; JOHN W. ATHENS, M.D., F.A.C.P.; MAXWELL M. WINTROBE, M.D., Ph.D., F.A.C.P.; and GEORGE E. CARTWRIGHT, M.D., F.A.C.P.
[+] Article and Author Information

Supported in part by grants AM-5098 and AM-04489, U. S. Public Health Service, Washington, D. C.

Dr. McArthur was supported in this study as an Advanced Clinical Fellow, 1965-1968, American Cancer Society, New York.

▸Requests for reprints should be addressed to James R. McArthur, M.D., University of Minnesota Hospitals, Minneapolis, Minn. 55455


Salt Lake City, Utah


Ann Intern Med. 1970;72(5):665-670. doi:10.7326/0003-4819-72-5-665
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Sixty-seven patients with symptomatic multiple myeloma were studied. Thirty-nine were treated with melphalan. The initial dose of 4 mg by mouth daily was reduced if the white blood count fell below 2,000 to 2,500/mm3. There were significant objective and subjective improvement and increased survival in the melphalan-treated patients as compared with a retrospective control group of 28 patients. The results compare favorably with reported series in which high-dose intermittent regimens were used. Information is insufficient to compare toxicity and complications associated with the two regimens.

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