0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Increased Opsonic Capacity of Serum in Chronic Heroin Addiction

D. SCOTT NICKERSON, B.S.; RALPH C. WILLIAMS JR., M.D.; MARGARET BOXMEYER, B.S.; and PAUL G. QUIE, M.D.
[+] Article and Author Information

Supported in part by grants #AI 08821-02 and AM AI 13824-01, the U. S. Public Health Service, Washington, D.C.; and in part by a grant from the New Mexico Arthritis Foundation, Albuquerque.

▸Requests for reprints should be addressed to Dr. Ralph C. Williams, Jr., Department of Medicine, Bernalillo County Medical Center, University of New Mexico School of Medicine, Albuquerque, N. M. 87106


Baltimore, Maryland; Albuquerque, New Mexico; and Minneapolis, Minnesota


Ann Intern Med. 1970;72(5):671-677. doi:10.7326/0003-4819-72-5-671
Text Size: A A A

Studies of phagocytosis promoting capacity and immunoglobulin levels were conducted in a group of 25 long-term heroin addicts. Sera were collected from addicts at Lexington, Ky.; Synanon House, San Francisco; and Albuquerque, N. M. Striking increments in heat-stable opsonins for Escherichia coli and Serratia marcescens were found in many addicts' sera as compared with normal control sera. Marked elevations of gamma M (up to 660 mg/100 ml) were found in many sera, accompanied by 19S antibacterial opsonins as demonstrated by separations in sucrose density gradients. Antigamma-globulin factors were present in 36% of the addicts studied. There was no impairment in ingestion or killing of test bacteria by polymorphonuclear leukocytes obtained from subjects on substitution narcotic therapy.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)