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Rheumatism and Chemotherapy of Tuberculosis

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Rheumatology Section, Veterans Administration Hospital, Ann Arbor, Mich.

Ann Intern Med. 1970;72(5):752-753. doi:10.7326/0003-4819-72-5-752
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Isoniazid arrived on the scene in America with remarkable news photographs of consumptives, involved in the first clinical trials, dancing in the wards at Sea View Hospital. Inexplicably, as the grip of bed rest began to relax, shoulder pain and stiffness received increasing attention (1-5). Among patients reported as victims of isoniazid-induced polyneuritis were those who in fact had little objective evidence for neuropathy but, rather, swelling, fibrosis, and progressive contractures of the hands (6). Nearly simultaneously in 1961 observers in France and the United States presented evidence that isoniazid (7) and ethionamide (8), a related drug, could induce a


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