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Erythropoiesis and Erythropoietin in Patients with Chronic Renal Failure Treated with Hemodialysis and Testosterone

[+] Article, Author, and Disclosure Information

Supported in part by the Argonne Cancer Research Hospital, Chicago, Ill.; grants HE-07969 and HE-09513, National Heart Institute, National Institutes of Health, Bethesda, Md.; and Veterans Administration research funds from Hines Veterans Administration Hospital, Hines, Ill.

Dr. DeGowin was supported in this study by research career development award 1-KO 3-CA15719-01, National Cancer Institute, National Institutes of Health. Dr. Lavender was supported by research career development award, National Heart Institute.

▸Requests for reprints should be addressed to Alexander Gottschalk, M.D., Argonne Cancer Research Hospital, 950 E. 59th St., Chicago, Ill. 60637

Chicago, Illinois

Ann Intern Med. 1970;72(6):913-918. doi:10.7326/0003-4819-72-6-913
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Testosterone was administered to two patients with chronic renal failure (one patient was anephric) who were being treated with periodic hemodialysis. The hematocrit and plasma erythropoietin levels increased in the patient with kidneys so that blood transfusions could be discontinued. When testosterone administration was stopped the hematocrit diminished, and blood transfusions were reinstated. Withholding blood transfusions from the anephric patient resulted in progressive anemia that stabilized at hematocrit values of less than 20%. Plasma erythropoietin levels increased, and enumeration of bone marrow normoblasts, ferrokinetic studies, and linear profile scanning showed increased erythropoiesis in response to the fall in hematocrit. Results of these studies should encourage further investigation of the efficacy of androgens in ameliorating the anemia in patients with chronic renal failure who have periodic hemodialysis.





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