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Normocalcemic Primary Hyperparathyroidism with Osteitis Fibrosa

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▸Requests for reprints should be addressed to Boy Frame, M.D., Henry Ford Hospital, Detroit, Mich. 48202

Detroit, Michigan

Ann Intern Med. 1970;73(2):253-257. doi:10.7326/0003-4819-73-2-253
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A 62-year-old woman with a 10-year history of repeated pathologic fractures was found at autopsy to have a parathyroid adenoma and osteitis fibrosa. Unusual features were normocalcemia and a marked elevation of the plasma alkaline phosphatase to 80 Bodansky units. Recently there has been increased emphasis on the occurrence of normocalcemia in patients with primary hyperparathyroidism. The great majority of such patients have exhibited renal calculi as the major feature of their parathyroid hyperfunction. The current case illustrates that osteitis fibrosa without renal calculi also occurs in normocalcemic hyperparathyroidism.





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