The full content of Annals is available to subscribers

Subscribe/Learn More  >
Ideas and Opinions |

Vascular Disease in Progressive Systemic Sclerosis (Scleroderma)

[+] Article, Author, and Disclosure Information

Presented in part as the Wallace Graham Memorial Lecture in September 1969 at Queens University, Kingston, Ontario, Canada.

▸Requests for reprints should be addressed to Walter L. Norton, M.D., 951 Court Ave., Memphis, Tenn. 38103

Memphis, Tennessee

Ann Intern Med. 1970;73(2):317-324. doi:10.7326/0003-4819-73-2-317
Text Size: A A A

Not only is the cause of progressive systemic sclerosis unknown, but there is no general agreement on the point of pathological impact. However, clinical, morphological, and functional observations provide a consistent body of evidence indicating widespread vascular abnormalities in the disease. Although characteristic arterial lesions have been recognized for many years, their frequency has generally been considered to be insufficient to account for the varied manifestations of progressive systemic sclerosis. Recent evidence suggests that the capillary bed may be a primary site of injury, and diffuse devascularization of multiple tissues may be a major consequence. On the basis of evidence reviewed, progressive systemic sclerosis should be classified as a vascular disease, and the primary site of injury is at the microvascular level.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.