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Deafness Complicating Antibiotic Therapy of Hepatic Encephalopathy

[+] Article, Author, and Disclosure Information

Supported in part by research grants AM-07417 and AM 5424-02, U. S. Public Health Service, Washington, D.C.

▸Requests for reprints should be addressed to Dennis Berk, M.D., Department of Medicine, Lemuel Shattuck Hospital, 170 Morton St., Jamaica Plain, Mass. 02130

Boston, Massachusetts

Ann Intern Med. 1970;73(3):393-396. doi:10.7326/0003-4819-73-3-393
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Five cases of ototoxicity associated with the oral administration of neomycin are reported. The absence of renal failure but the presence of low serum antibiotic levels in these cases suggests that with prolonged exposure even minimal absorption can be toxic. Additional observations suggest that the related drug paromomycin may be similarly dangerous.





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