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Copper-Induced Acute Hemolytic Anemia: A New Complication of Hemodialysis

ALAN D. MANZLER, M.D.; and A. WILLIAM SCHREINER, M.D., F.A.C.P.
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▸Requests for reprints should be addressed to Alan D. Manzler, M.D., The Christ Hospital, 2139 Auburn Ave., Cincinnati, Ohio 45219


Cincinnati, Ohio


Ann Intern Med. 1970;73(3):409-412. doi:10.7326/0003-4819-73-3-409
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Three episodes of copper-induced acute hemolysis after hemodialysis in two patients and two uneventful exposures to copper in a third patient are reported. The clinical syndrome of copper intoxication is described. Contaminated dialysate was caused by copper that was released from copper tubing in the dialysate-making equipment when a deionizing system was exhausted, allowing acid water to be delivered to the dialysate-making equipment. Dialysate and plasma copper levels are correlated with symptoms and hemolysis. Corrections have been made to eliminate this potentially lethal complication of hemodialysis.

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