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Thromboembolism, Oral Contraceptives, and Cigarettes

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University of Tennessee College of Medicine, Memphis, Tenn.

Ann Intern Med. 1970;73(3):387-392. doi:10.7326/0003-4819-73-3-486
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Has thromboembolism mortality increased in women of childbearing age since the widespread use of oral contraceptives? In a recent paper Drs. Frederiksen and Ravenholt (1) analyze U.S. mortality data on lines similar to previous analyses of this question by both British and American investigators.

In 1968 Vessey and Weatherall (2) reported on mortality risks from venous thromboembolic disease (International Classification of Diseases (ICD) 463 to 466)* in women aged 20 to 44 years in England and Wales over the period 1953 to 1967. These diseases include thrombophlebitis of lower extremity (ICD 463); thromobophlebitis of other sites (ICD 464);


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