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Centrilobular Hepatic Necrosis and Acute Renal Failure in "Solvent Sniffers"

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▸Requests for reprints should be addressed to Daniel V. Kimberg, M.D., Beth Israel Hospital, 330 Brookline Ave., Boston, Mass. 02215

New York, New York; and Boston, Massachusetts

Ann Intern Med. 1970;73(5):713-720. doi:10.7326/0003-4819-73-5-713
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Three teenagers with a history of drug abuse developed acute hepatic injury after the inhalation of Carbona® cleaning fluid, a commercial preparation that contains trichloroethylene. Two of these patients had evidence of acute renal injury, presumably due to tubular necrosis. Electrocardiographic and electroencephalographic abnormalities were also noted. Hepatic biopsies in two patients showed acute centrilobular necrosis. Both biopsies also showed evidence of mild centrilobular fibrosis, probably a result of previous injury from exposure to trichloroethylene. Carbona "sniffing" seems to be increasingly popular among adolescents, and its use in a group that has abused other drugs complicates an already difficult situation.





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