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A Double-Blind Study of Azaribine in the Treatment of Psoriasis

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Supported by a grant from the Medical Section, Emory University Clinic, Atlanta, Ga.; and Calbiochem, Los Angeles, Calif.

▸Requests for reprints should be addressed to William R. Vogler, M.D., 718 Woodruff Bldg., Emory University, Atlanta, Ga. 30322

Atlanta, Georgia

Ann Intern Med. 1970;73(6):951-956. doi:10.7326/0003-4819-73-6-951
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A double-blind study of the effect of 6-azauridine triacetate (azaribine) in psoriasis was conducted. One group received azaribine in a dose of 200 mg/kg of body weight per day for 6 weeks. The second group received placebo. Patients who failed to improve or relapsed were switched to the other group (studies A and B). Responses were judged as follows: excellent (complete clearing of lesions), good (75% reduction in size and thickness of lesions), fair (50% reduction in size and thickness of lesions), no improvement, and worse. After the double-blind study 11 patients were treated with azaribine in a dose of 100 mg/kg of body weight per day for 12 weeks (study C). Nine were then treated with optimal dose (study D). Twenty-two patients completed studies A and B. The responses to azaribine were 5, excellent; 11, good; 2, fair; 1, no improvement; and 3, worse. The responses to placebo were 0, excellent; 2, good; 2, fair; 1 no improvement; and 17, worse. The responses in study C were 1, excellent; 7, good; and 3, fair; and in study D there were 7 good and 2 fair. Mild marrow depression was the only toxicity observed.







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