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Osteoporosis and Corticoid Drugs

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Metabolic Research Unit, Creighton University, Department of Internal Medicine, Omaha, Neb.

Ann Intern Med. 1970;73(6):1038. doi:10.7326/0003-4819-73-6-1038_1
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Osteoporosis with fracture is an integral part of Cushing's syndrome when caused by adrenal tumor or hyperplasia. The mechanisms responsible have been unclear, but Follis (1), using standard morphological techniques, noted very few osteoblasts and no osteoclasts in osteoporotic bone from autopsy specimens. Sissons (2) described diminished osteoblasts on bone surfaces and a scarcity of osteoid borders. Both investigators concluded that impaired bone formation was an important component of the bone disease in Cushing's syndrome. Sisson's finding of retarded fracture callus formation has been confirmed experimentally in animals. Recently Jowsey and Riggs (3) studied undecalcified sections of bone labeled


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