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The Coexistence of Sjögren's Syndrome and Systemic Lupus Erythematosus

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▸Requests for reprints should be addressed to Alfred D. Steinberg, M.D., Building 10, Rm. 9N-210, National Institutes of Health, Bethesda, Md. 20014

Bethesda, Maryland

Ann Intern Med. 1971;74(1):55-61. doi:10.7326/0003-4819-74-1-55
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Eight patients with features of both Sjögren's syndrome and systemic lupus erythematosus are presented. Clinical and laboratory findings in these patients form a spectrum of disease. Outstanding laboratory features are marked hypergammaglobulinemia, destructive salivary gland lymphoid infiltration, and uniform presence of anti-DNA antibodies. Three patients had severe renal disease of lupus erythematosus in addition to classical Sjögren's syndrome, an unusual combination. Patients with coexistent Sjögren's syndrome and systemic lupus erythematosus have hyperactivity of both humoral and cellular immune systems.





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