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Vaccine Prophylaxis for Pseudomonas Infections

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Laboratory of Biochemical Pharmacology, National Institute of Arthritis and Metabolic Diseases, National Institutes of HealthBethesda, Md.

Ann Intern Med. 1971;74(1):140. doi:10.7326/0003-4819-74-1-140
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The development of an effective pseudomonas vaccine for the prophylaxis of fatal pseudomonas infection in burned patients has been reported by Fisher and his co-workers (1-3). This event is the culmination of a number of various investigations.

In spite of the fact that burned animals are more susceptible to Pseudomonas aeruginosa infections than normal animals (4, 5), their antibody production against chemical antigens (6-8), as well as particulate antigens such as sheep erythrocytes (9) and bacteria (10), rises to the same levels as that observed in normal animals. For this reason active immunization seemed feasible. Specific (5, 11) as well


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