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The Pharmacological Basis of Therapeutics.

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Fourth Edition. Edited by Goodman Louis S.. , M.D., and Gilman Alfred. , Ph.D. 1794 pages. The Macmillan Co., New York: ; Collier-Macmillan Ltd., London: ; and Collier-Macmillan Canada Ltd., Toronto: , 1970.. Price, $25.00.

Ann Intern Med. 1971;74(1):149. doi:10.7326/0003-4819-74-1-149_1
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As noted in the preface by the editors, by historic accident each edition of the "blue bible" has appeared at a strategic period of the medical and pharmacological sciences. The eminent pharmacologist, Dr. Carl Schmidt, observed that the first edition (1941) appeared when materia medica was giving way to modern scientific pharmacology; the second (1954) after an era of spectacular advances in microbial chemotherapy by the development of many new "wonder drugs"; and the third (1965) when the flood of new drugs had begun to subside for a variety of reasons, including federal legislation resulting from unfortunate drug toxicities and


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