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Iron, Arthritis, and Anemia

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Mayo Clinic, Rochester, Minn.

Ann Intern Med. 1971;74(2):292-293. doi:10.7326/0003-4819-74-2-292
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In the May 1970 issue of the Australasian Annals of Medicine, Muirden described his studies of the iron content of synovial membranes in 81 patients with rheumatoid arthritis (1). The conclusions drawn from these studies are that heavy synovial deposits of ferritin and hemosiderin are probably the rule in rheumatoid arthritis and that the intensity of these deposits correlates strongly with the occurrence and severity of anemia.

The association of iron-laden synovia with arthropathy was first described in osteoarthrosis deformans, but whether synovial hemosiderosis is a common occurrence in this disease has not been clearly established. The intensive synovial deposition



anemia ; arthritis ; iron

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