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Hypocalcemia and Osteomalacia Associated with Anticonvulsant Therapy

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Department of Medicine, Henry Ford Hospital, Detriot, Mich.

Ann Intern Med. 1971;74(2):294-295. doi:10.7326/0003-4819-74-2-294
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It is commonly known that hypocalcemia can cause a variety of epileptic seizure patterns. That anticonvulsants used in the therapy of epilepsy can diminish the signs of tetany and tetanic equivalents in patients with hypocalcemia is less commonly recognized (1). Thus hypocalcemia may be overlooked as a cause of epilepsy if anticonvulsants are inadvertently administered for hypocalcemic convulsions. Recent reports from Europe now suggest that long-term anticonvulsant therapy may also initiate serum chemical and histologic changes of osteomalacia. These new observations can be logically accounted for by new findings in vitamin D metabolism.

In 1968 Kruse reported that 15% of


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