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Metastatic Insulinoma Treated with Streptozotocin

PAUL H. SCHREIBMAN, M.D.; LIDIA GORANSKY DE KOLIREN, M.D.; and RONALD A. ARKY, M.D.
[+] Article and Author Information

The authors wish to express their appreciation to Drs. Albert Poirier and Gerald Faich for referral of the patient, to Dr. Stephen Carter for helpful advice, and to Dr. Ronald Duffield for interpretation of the liver scans.

▸Requests for reprints should be addressed to Ronald Arky, M.D., Thorndike Memorial Laboratory, Boston City Hospital, Boston, Mass. 02118


Boston, Massachusetts


Ann Intern Med. 1971;74(3):399-403. doi:10.7326/0003-4819-74-3-399
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A patient with hepatic metastases of an insulin-producing islet cell carcinoma has been successfully treated with streptozotocin. At 6 months posttreatment, liver scans demonstrate complete regression of tumor, and blood glucose and insulin levels have returned to normal. The pharmacology of and indications for streptozotocin (a 1-methyl, nitrosourea-glucosamine antitumor antibiotic) are discussed.

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