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Phosphoribosylpyrophosphate in Man: Biochemical and Clinical Significance

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Supported in part by research grant A14362, research grant AM12413, and Clinical Research Center grant MO 1 RR-30, U.S. Public Health Service, Washington, D.C. Dr. Fox was supported in part by a Postdoctoral Fellowship from the Medical Research Council of Canada. Dr. Kelley is a Clinical Scholar of The Arthritis Foundation, New York, N.Y.

▸Requests for reprints should be addressed to William N. Kelley, M.D., Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, N.C. 27707

Durham, North Carolina

Ann Intern Med. 1971;74(3):424-433. doi:10.7326/0003-4819-74-3-424
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The intracellular concentration of phosphoribosylpyrophosphate (PRPP), a high-energy 1,5-substituted ribose sugar, has been demonstrated to have a critical role in the regulation of purine metabolism in man. Increased intracellular levels of PRPP may be important in the pathogenesis of excessive uric acid production observed in some patients with primary gout, the Lesch-Nyhan syndrome, and glycogen storage disease type I. In addition, the alteration of intracellular PRPP by several compounds including allopurinol, orotic acid, adenine, 2,6-diaminopurine, methylene blue, and certain trophic hormones may account for some of the effects of these agents.





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