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Alcoholic Hepatitis

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University of Southern California School of Medicine, Los Angeles, Calif.

Ann Intern Med. 1971;74(3):440-442. doi:10.7326/0003-4819-74-3-440
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Cirrhosis and fatty liver have been recognized as sequels of alcoholism for many years. Surprisingly, until recently there has been only sporadic interest in the consequences of acute hepatocyte injury produced by alcoholism. The hallmarks of this injury, as described by Helman, Temko, Nye, and Fallon in this issue of the ANNALS (pp. 311-321), are swelling and degeneration of hepatocytes, formation of alcoholic hyaline, and infiltration by polymorphonuclear leukocytes. F. B. Mallory first drew attention to this lesion in 1911 (1). Since then clinicians and pathologists have used various terms for the clinicopathologic syndrome, including "acute hepatic insufficiency of the


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