0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Liver Disease in Crohn's Colitis: A Study of 21 Consecutive Patients Having Colectomy

M. N. EADE, M.D., M.R.C.P.; W. T. COOKE, M.D., F.R.C.P.; B. N. BROOKE, M.D., M.Chir.; and H. THOMPSON, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to W. T. Cooke, M.D., Consultant Physician, The General Hospital, Birmingham 4, England.


Auckland, New Zealand; and Birmingham and London, England


Ann Intern Med. 1971;74(4):518-528. doi:10.7326/0003-4819-74-4-518
Text Size: A A A

Twenty-one consecutive patients undergoing colectomy for Crohn's disease of total colon were studied, with particular emphasis on hepatic abnormality at colectomy and at 3- to 7-year follow-up. After colectomy there was a high incidence of recurrent Crohn's disease involving small bowel, regardless of initial small-bowel involvement. There were abnormalities of liver histology in 90% of the 20 operative biopsies, with 75% showing more than minor change. Cirrhosis, amyloidosis, and multiple hepatic granulomata were also noted. Elevated serum alkaline phosphatase was of value in detecting significant hepatic abnormality. Other tests were not as useful, being either too insensitive (such as serum bilirubin and serum transaminases) or too nonspecific (serum protein abnormalities and sulfobromophthalein retention). Blood transfusions, potentially hepatotoxic drugs, and previous hepatitis appeared unrelated to observed hepatic abnormalities. The frequency and type of hepatic abnormality encountered in Crohn's colitis was similar to that previously reported in ulcerative colitis and Crohn's disease predominantly affecting the small intestine.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)