0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Case Reports |

An Unusual Type of Spiculated Erythrocyte in Metastatic Liver Disease and Hemolytic Anemia: Report of a Case

JAMES W. KELLER, M.D.; PHILIP W. MAJERUS, M.D.; and EDWARD H. FINKE, B.S.
[+] Article and Author Information

Supported in part by grants AM 10550 and HE 00022, U.S. Public Health Service, Washington, D.C.; grant PRA 33, American Cancer Society, New York, N.Y.; and grant RR 36, National Institutes of Health Clinical Research Center, Bethesda, Md. The Scanning Electron Microscope was supported by Health Science Award F-304-FR 06115 to Washington University.

Dr. Keller is a recipient of U.S. Public Health Services Graduate Training Grant AM 05089, and Dr. Majerus is a Teaching and Research Scholar of the American College of Physicians, Philadelphia, Pa.

▸Requests for reprints should be addressed to Philip W. Majerus, M.D., Division of Hematology, 4550 Scott Ave., St. Louis, Mo. 63110


St. Louis, Missouri


Ann Intern Med. 1971;74(5):732-737. doi:10.7326/0003-4819-74-5-732
Text Size: A A A

A patient had hemolytic anemia associated with spiculated erythrocytes and massive hepatic metastases from rectal carcinoid. The patient's erythrocytes resembled acanthocytes found in abetalipoproteinemia when examined by scanning electron microscopy. The patient's erythrocytes contained normal quantities of cholesterol, and his serum did not transform normal erythrocytes into spiculated cells in vitro. Normal erythrocytes infused into the patient did not acquire the filtration properties of acanthocytes, yet their survival was shortened, suggesting that the mechanism of hemolysis was independent of acanthocyte formation. These findings are discussed in relation to the acanthocytes found in other liver diseases. The great variability in results obtained studying the mechanism of acanthocyte formation suggest that multiple factors may lead to their formation.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)