The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Uricosuric Effect of Radiocontrast Agents: A Study in Man of Four Commonly Used Preparations

[+] Article, Author, and Disclosure Information

Supported in part by grant #MO 1 RR-30, Clinical Research Center, National Institutes of Health, Bethesda, Md. 20014. Dr. Kelley is a Clinical Scholar, The Arthritis Foundation, New York, N.Y.

▸Requests for reprints should be addressed to W. N. Kelley, M.D., Box 211, Duke University Medical Center, Durham, N.C. 27706

Durham, North Carolina

Ann Intern Med. 1971;74(6):845-852. doi:10.7326/0003-4819-74-6-845
Text Size: A A A

The administration of standard doses of four commonly used radiocontrast agents, iopanoic acid (Telepaque®), calcium ipodate (Oragrafin®), meglumine iodipamide (Cholografin®), and sodium diatrizoate (Hypaque®) to 2 to 12 patients is followed by a decrease in the serum urate concentration, an increase in the urinary excretion of uric acid, and an increase in the renal clearance of uric acid. This uricosuric effect of these agents appears to be caused by enhanced renal tubular secretion of uric acid. Telepaque and Oragrafin were found to have a more potent effect than Cholografin and Hypaque. In addition, the duration of the uricosuric effect of these agents, which is 5 and 6 days for Telepaque and Oragrafin, respectively, and 1 day for Cholografin and Hypaque, correlates with the duration of their reported renal excretion. The possibility that acute renal failure occasionally precipitated by these agents may be related to their uricosuric effect is discussed.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.