The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Articular Manifestations of Systemic Lupus Erythematosus

[+] Article, Author, and Disclosure Information

Supported by grants from the Veteran's Administration, Washington, D.C., and the Eastern Pennsylvania Chapter of the Arthritis Foundation, Philadelphia, Pa.; and grant 5Mo1RR40 from the Clinical Research Center, Division of Research Resources, National Institutes of Health, Bethesda, Md.

▸Requests for reprints should be addressed to H. Ralph Schumacher, Jr., M.D., 206 Maloney Building, Hospital of the University of Pennsylvania, 36th & Spruce Sts., Philadelphia, Pa. 19104

Philadelphia, Pennsylvania

Ann Intern Med. 1971;74(6):911-921. doi:10.7326/0003-4819-74-6-911
Text Size: A A A

We have studied 25 patients with classical systemic lupus erythematosus and joint manifestations to characterize features of the arthritis that may suggest this diagnosis. Objective arthritis was seen in 19 patients (76%) and was usually mild. There was no destructive joint disease except for 4 patients who developed aseptic necrosis while on corticoid therapy. Synovial fluids showed less intense inflammation than in rheumatoid arthritis and did not always reflect the degree of inflammation that was occurring in the synovial membrane. Antinuclear factors, lupus erythematosus cells, and lowered total hemolytic complement were seen in some effusions. Light and electron microscopy of synovial biopsies from 7 patients showed synovial lining cell proliferation and microvascular changes including occasional vasculitis and various degrees of inflammatory cell infiltration. Microtubular paramyxovirus-like inclusions were seen in venular endothelial cells of two patients. Small vessel changes appear to be playing an important role in the pathogenesis of the articular disease.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.