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Primary Amoebic Meningoencephalitis Caused by Naegleria: Two New Cases, Response to Amphotericin B, and a Review

RICHARD J. DUMA, M.D., F.A.C.P.; WILLIAM I. ROSENBLUM, M.D.; READ F. MCGEHEE, M.D.; MURIEL M. JONES, M.S.; and E. CLIFFORD NELSON, SC.D
[+] Article and Author Information

Presented in part on 16 April 1970 at the 51st Annual Session of the American College of Physicians, Philadelphia, Pa.

▸Requests for reprints should be addressed to Richard J. Duma, M.D., Box 92, Medical College of Virginia, Richmond, Va. 23219


Richmond, Virginia


Ann Intern Med. 1971;74(6):923-931. doi:10.7326/0003-4819-74-6-923
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Two new cases of primary amoebic meningoencephalitis and two previously reported cases are presented as the basis for a description of the clinical, pathological, epidemiological, and protozoological aspects of this infection. The patients acquired their illnesses from swimming in fresh water; the infections were culturally proved to be caused by free-living amoeboflagellates of the genus Naegleria. The infections were rapidly fatal, but in two cases the responsible pathogens were markedly inhibited in vivo (as well as in vitro) by amphotericin B; at present this drug appears to be the only promising treatment available for an otherwise fatal disease.

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