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Hydronephrosis, Bacteriuria, and Maximal Urine Concentration in Urinary Schistosomiasis

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Presented in part 14 April 1970 at the 51st Annual Session of the American College of Physicians, Philadelphia, Pa.

Supported by Research Project MR005.20.01.0307A, Bureau of Medicine and Surgery, Department of the Navy, Washington, D.C. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or of the naval service at large.

▸Requests for reprints should be addressed to Medical Department, NAMRU-3, Fleet Post Office, N.Y., 09527

Cairo, Egypt

Ann Intern Med. 1971;75(1):49-55. doi:10.7326/0003-4819-75-1-49
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Renal function was studied in 84 male patients with Schistosoma haematobium infection. Maximal urine concentration, creatinine clearance, and intravenous urography were obtained. Patients were placed in four groups: A, 32 patients with nonobstructive urographic abnormalities and negative urine cultures; B, 24 patients with bilateral hydronephrosis and negative urine cultures; C, 13 patients with nonobstructive urographic abnormalities and bacteriuria; and, D, 15 patients with bilateral hydronephrosis and bacteriuria. Maximal urine concentration in groups B, C, and D was significantly lower than in group A. After antischistosomal and antimicrobial therapy, reduction of hydronephrosis and bacteriuria was associated with significantly increased maximal urine concentration. Creatinine clearance did not change after treatment. The results of this study suggest that hydronephrosis or bacteriuria alone impairs urine concentration, that the effects of both abnormalities on renal concentrating mechanisms may be additive, and that impaired urine concentration owing to either or both is reversible.





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