0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Case Reports |

Variant "Goodpasture's Syndrome"?: The Need for Immunologic Criteria in Rapidly Progressive Glomerulonephritis and Hemorrhagic Pneumonitis

JOSE S. MARTINEZ, M.D.; and PETER F. KOHLER, M.D.
[+] Article and Author Information

Supported in part by grants HD03381-03 and AI00013-12, National Institutes of Health, Bethesda, Md. Dr. Kohler is a recipient of a Research Career Development Award, HD 42,404-02, National Institute of Child Health and Human Development, National Institutes of Health.

▸Requests for reprints should be addressed to Peter F. Kohler, M.D., University of Colorado Medical Center, Denver, Colo. 80220


Ann Intern Med. 1971;75(1):67-76. doi:10.7326/0003-4819-75-1-67
Text Size: A A A

The immunopathogenic mechanisms in three men with rapidly progressive glomerulonephritis and hemorrhagic pneumonitis were studied. Nephritis and fatal pulmonary hemorrhage occurred simultaneously in two patients. Typical Goodpasture's syndrome was defined in one by the presence of noncomplement-fixing IgG antiglomerular basement membrane (GBM) antibodies in his circulation, kidney, and lung. Immunofluorescent studies were negative in the second patient, although an immune complex pathogenesis was suggested by the presence of mixed cryoglobulinemia, decreased serum complement, and arteritis. The third patient also had anti-GBM-mediated nephritis, but his ultimately fatal pulmonary disease did not develop until after nephrectomy. Recurrence of the same anti-GBM nephritis was documented in his renal transplant at necropsy. It is suggested that "Goodpasture's syndrome" be restricted to patients with anti-GBM antibody-mediated nephritis and concomitant hemorrhagic pneumonitis.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)