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Rheumatoid Arthritis Associated with Eosinophilia

RICHARD S. PANUSH, M.D.; ALEJANDRO E. FRANCO, M.D.; and PETER H. SCHUR, M.D., F.A.C.P.
[+] Article and Author Information

This work was supported by grants AM 11414, AM 05577, AM 12051, and AM 5076, U.S. Public Health Service, Washington, D.C. Drs. Panush and Franco were Clinical Fellows of the National Institute of Arthritis and Metabolic Disease, National Institutes of Health, Bethesda, Md., during the time of this study.

▸Requests for reprints should be addressed to Peter H. Schur, M.D., Robert B. Brigham Hospital, Boston, Mass. 02120


Boston, Massachusetts


Ann Intern Med. 1971;75(2):199-203. doi:10.7326/0003-4819-75-2-199
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Five patients with classical rheumatoid arthritis and peripheral eosinophilia ranging from 20% to 89% are described. These patients had clinical and radiological findings of severe, deforming articular disease and a high prevalence of rheumatoid vasculitis, pleuritis, and subcutaneous nodules. As a group they had relatively low serum complement, high serum antigammaglobulin, and increased serum IgG, IgG1, lgG3, and IgM levels. These findings may reflect intense immunologic stimulation. In susceptible hosts this stimulus may be able to induce the profound eosinophilia observed.

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