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Hemolytic Anemia Caused by G-6-PD Carswell, A New Variant

[+] Article, Author, and Disclosure Information

Supported in part by USPHS grant HE07449 from the National Heart Institute, National Institutes of Health, Bethesda, Md.

▸Requests for reprints should be addressed to Ernest Beutler, M.D., City of Hope Medical Center, 1500 E. Duarte Rd., Duarte, Calif. 91010

New York, New York, and Duarte, California

Ann Intern Med. 1971;75(3):437-439. doi:10.7326/0003-4819-75-3-437
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An 18-year-old man of Irish ancestry was found to have hemolytic anemia associated with a deficiency of red-cell glucose-6-phosphate dehydrogenase. Characterization of the partially purified enzyme showed it to differ from previously described variants. It was electrophoretically slow, showed decreased activity with deamino nicotinamide-adenine dinucleotide phosphate (NADP), and was stable to heat. The abnormal enzyme has been named G-6-PD Carswell.





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