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The Dynamic Nature of Left Ventricular Outflow Obstruction in Idiopathic Hypertrophic Subaortic Stenosis

D. LUKE GLANCY, M.D., F.A.C.P.; RICHARD L. SHEPHERD, M.D.; G. DAVID BEISER, M.D.; and STEPHEN E. EPSTEIN, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to D. Luke Glancy, M.D., Chief, Cardiovascular Diagnosis Section, Cardiology Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Md. 20014


Ann Intern Med. 1971;75(4):589-592. doi:10.7326/0003-4819-75-4-589
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Hemodynamic changes occurring with spontaneous atrioventricular dissociation, left ventricular pulsus alternans, a rise in systemic arterial pressure, and the injection of angiographic contrast material support the hypothesis that in a given patient with idiopathic hypertrophic subaortic stenosis the degree of left ventricular outflow obstruction is determined by three factors: the force of left ventricular contraction, ventricular volume, and ventricular afterload.

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