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The Place of Genetics in Medicine

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▸Requests for reprints should be addressed to Curt Stern, Zoology Department, University of California, Berkeley, Calif. 94720

Berkeley, California

Ann Intern Med. 1971;75(4):623-629. doi:10.7326/0003-4819-75-4-623
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This convocation oration surveys a number of areas in human genetics that are relevant to medical practice. Among the topics dealt with are premendelian empirical findings on transmission of disease states and their later rational interpretation in terms of mendelian genes, genetic counseling, treatments of inborn errors of metabolism, amniocentesis and pregnancy termination, pharmacogenetics, and linkage studies of the genes in human chromosomes as tools in genetic prognosis. Ethical problems are dealt with, such as problems related to secrecy concerning genetic defects, therapeutic abortions, increases in the load of mutations in the human gene pool because of therapeutic successes, deliberate manipulation of genes at the biochemical level, and differential reproduction of genetically different population samples, as well as experimental embryological methods applied to humans, such as cloning.







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