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Drug Interference with Measurement of Adrenal Hormones in Urine: Analgesics and Tranquilizer-Sedatives

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Dr. Cryer is a Teaching and Research Scholar of the American College of Physicians, Philadelphia, Pa. This study was carried out under the auspices of Research Task Number M4305.53056A662, Navy Department, Washington, D.C.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

▸Requests for reprints should be addressed to Philip E. Cryer, M.D., Department of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110

Bethesda, Maryland

Ann Intern Med. 1971;75(5):697-702. doi:10.7326/0003-4819-75-5-697
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Twenty-four-hour urinary 17-hydroxycorticoids, free 11-hydroxycorticoids, 17-ketosteroids, and catecholamines were measured repetitively in a volunteer subject during control and base-line periods and during the short-term ingestion of relatively small doses of commonly used analgesic and tranquilizer-sedative drugs. The ingestion of propoxyphene, 65 mg, three times daily, was associated with significant depression of the urinary 17-hydroxycorticoids and 17-ketosteroids; significant depression of the 17-hydroxycorticoids and free 11-hydroxycorticoids occurred during the ingestion of pentazocine, 50 mg, twice daily. In the dosages used, the short-term ingestion of acetylsalicylic acid, acetaminophen, chlordiazepoxide, diazepam, phenobarbital, or diphenhydramine did not interfere with the measurement of 17-hydroxycorticoids, free 11-hydroxycorticoids, or 17-ketosteroids in the urine. None of the drugs tested interfered with the measurement of urinary catecholamines, norepinephrine, or epinephrine.





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