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Altered Peritoneal Permeability in Patients with Systemic Vasculitis

KARL D. NOLPH, M.D., F.A.C.P.; MICHAEL L. STOLTZ, M.D.; and JOHN F. MAHER, M.D., F.A.C.P.
[+] Article and Author Information

Presented in part at the Midwestern Section Meetings of the American Federation for Clinical Research, 5 November 1970, Chicago, Ill.

▸Requests for reprints should be addressed to Karl D. Nolph, M. D., Department of Medicine, Division of Nephrology, University of Missouri Medical Center, Columbia, Mo. 65201


Columbia, Missouri, and Washington, D.C.


Ann Intern Med. 1971;75(5):753-755. doi:10.7326/0003-4819-75-5-753
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Decreased peritoneal membrane permeability should impair the transperitoneal diffusion of larger molecular weight solutes more than that of smaller solutes during peritoneal dialysis. To see if systemic vascular disease produces such selective functional alterations in man, peritoneal clearances of urea (Curea), creatinine (Ccr) and urate (Curate) were measured in four patients with severe systemic vascular disease. Mean values for Curea, Ccr/Curea, and Curate/Curea in the study patients were significantly (P < 0.01) below values for these functions in the control group. The selective reductions in the clearances of higher molecular weight solutes suggest alterations of functional permeability of the peritoneal capillaries or mesothelium, or both, in patients with systemic vascular disease.

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