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Ann Intern Med. 1971;75(5):795-797. doi:10.7326/0003-4819-75-5-795
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Biochemical discoveries concerning the role and localization of dopamine in the central nervous system led to the use of levodopa therapy for Parkinson's disease. These discoveries now are generally recognized as representing a major and exciting advance in the understanding of neurologic illness. The clinical success of levodopa therapy has been a forceful stimulus to further biochemical investigations of neurologic diseases.

The article by Lee, Sweet, and McDowell* in this issue summarizes a 2-year experience with levodopa therapy, and few would disagree with the reported clinical observations or with most of the conclusions. Several points should be emphasized.

Tremor is




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