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Five Families with Multiple Endocrine Adenomatosis

NED SNYDER III, M.D.; MURPHY T. SCURRY, M.D.; and WILLIAM P. DEISS JR., M.D.
[+] Article and Author Information

Supported in part by grant RR-73 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health, Bethesda, Md.

Presented in part 16 April 1970 at the 51st Annual Session, American College of Physicians, Philadelphia, Pa.

▸Requests for reprints should be addressed to Murphy T. Scurry, M.D., Department of Medicine, University of Texas Medical Branch, Galveston, Tex. 77550


Galveston, Texas


Ann Intern Med. 1972;76(1):53-58. doi:10.7326/0003-4819-76-1-53
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Members of five families, in whom at least one member was known to have multiple endocrine tumors, were screened for involvement with multiple endocrine adenomatosis. Of 27 family members who had not been previously studied, 8 were found to have hypercalcemia, of whom 7 were asymptomatic. All families had members with parathyroid and pancreatic islet cell tumors, and some families also had pituitary tumors, lipomas, and bronchial carcinoids. In the total sample of 38 patients the commonest abnormality was hypercalcemia, and the next commonest was pancreatic tumors. The most useful screening methods were taking clinical histories and evaluating serum calcium. We conclude that all family members of patients with multiple endocrine adenomatosis should be studied for possible involvement.

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