0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Chronic Hepatitis As a First Manifestation of Wilson's Disease

IRMIN STERNLIEB, M.D.; and I. HERBERT SCHEINBERG, M.D.
[+] Article and Author Information

Supported in part by grants AM1059 and 5MO1-RR-50 from the U.S. Public Héalth Service, Washington, D.C., and the Yvonne Rogers Memorial Fund.

We are grateful to Drs. Daniel L. Anderson, Arthur Berken, David J. Gocke, Kermit Pines, Fenton Schaffner, and W. F. Vogel for providing information on their patients.

▸ Requests for reprints should be addressed to Irmin Sternlieb, M.D., Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, N.Y. 10461


Bronx, New York


Ann Intern Med. 1972;76(1):59-64. doi:10.7326/0003-4819-76-1-59
Text Size: A A A

In four males and three females, from 12 to 28 years of age, chronic hepatitis was diagnosed because of manifestations indistinguishable from those generally associated with this disease. From 3 months to 4½ years after the onset of hepatic illness, persistence of the hepatic disorder for 4 years in one boy, a diagnosis of Wilson's disease in one girl's sibling, the development of neurologic symptoms in four of these patients, and the accidental discovery of Kayser-Fleischer rings in a man led to the suspicion of Wilson's disease in each of the seven patients. Although copper toxicity is etiologic in probably no more than 5% of patients with chronic hepatitis, it is susceptible to specific and effective pharmacologic therapy, unlike most other forms of hepatitis. Consequently, the disease should be borne in mind and the concentration of ceruloplasmin in serum measured in every child or young adult under 30 years of age with idiopathic chronic hepatitis.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)