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Defibrination in Acute Pancreatitis

[+] Article and Author Information

▸ Requests for reprints should be addressed to Harvey R. Gralnick, M.D., Hematology Service, Clinical Pathology Department, Clinical Center, Bldg. 10, Room 5N-236, National Institutes of Health, Bethesda, Md. 20014

Bethesda, Maryland

Ann Intern Med. 1972;76(1):73-76. doi:10.7326/0003-4819-76-1-73
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Coagulation abnormalities in clinical and experimental pancreatitis have been described. The release of proteolytic enzymes from the inflamed pancreas has been postulated as the cause of observed coagulation abnormalities. This report describes a patient who developed acute pancreatitis with severe coagulation abnormalities. Increased proteolytic activity was shown in the patient's serum and plasma and was associated with defibrination, accelerated use of fibrinogen, and other coagulation factors. The coagulation abnormalities improved as the proteolytic activity declined, and the pancreatitis abated.





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